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Need to know
Hepatitis C virus (HCV) – one of the major causes of chronic liver diseases, including cirrhosis and hepatocellular carcinoma, and is the main indication for liver transplantation. In the world, hepatitis C virus (HCV) infected about 170 mln people. The criterion of virus elimination and thus cure for chronic hepatitis C is now considered sustained viral response – negative qualitative test for HCV RNA in 6 months upon completion of treatment
On the basis of the dynamics of viral load (HCV RNA concentration in plasma), quick and early virologic response at 4 and 12 weeks after initiation of treatment are determined respectively, and the virologic response at the end of the course of antiviral therapy and relapse rate after its completion. First two indicators can predict probability of persistent response in patients with 1 HCV genotype and hence the need to continue treatment. The last two indicators make it possible to judge the effectiveness of a completed course of antiviral therapy, but do not replace the definition of SVR.